Gene Ontology
There are three aspects to gene ontology:
1: biological processes: which of the cell's activities the gene product is involved in 2: cellular components: what parts of a cell the gene product is involved in 3: molecular functions: what a gene product (RNA, protein) interacts with molecularly The Gene Ontology for MCM6: [2] Biological Processes: DNA replication initiation DNA strand elongation during DNA replication DNA unwinding during DNA replication G1/S transition of mitotic cell cycle M/G1 transition of mitotic cell cycle S phase of mitotic cell cycle Cell cycle checkpoint Cellular Components: MCM complex Nucleoplasm Molecular Functions: ATP binding DNA helicase activity Single-stranded DNA binding Additional Helpful Web Resources: SMART accession number: SM00350 AmiGO Gene Ontology for MCM6 PFAM: MCM6_HUMAN (Q14566) |
Figure 1: This image is the basic structure of a cell. MCM6 functions primarily in the nucleoplasm, which is the fluid inside the nucleus (pink sphere). This is where all of the biological processes which MCM6 is involved with take place; the reason for this is because DNA is stored within the nucleus and cellular replication begins with DNA replication initiation [3].
Figure 2: This image is of mitosis, or cellular replication [3]. MCM6 is involved with many of the processes involved in mitosis.
|
ANALYSIS AND DISCUSSION
From these processes, components and functions, it is clear what the cell does with the MCM6 gene.
In a sentence: MCM6 is involved in cell cycle regulation and initiation of replication, within the nucleoplasm as a part of the MCM complex, by binding to ATP and single-stranded DNA.
In a sentence: MCM6 is involved in cell cycle regulation and initiation of replication, within the nucleoplasm as a part of the MCM complex, by binding to ATP and single-stranded DNA.
REFERENCES
[1] "SMART: MCM Domain Annotation." SMART: MCM Domain Annotation. EMBL, 2012. Web. 21 Feb. 2013. <http://smart.embl-heidelberg.de/smart/do_annotation.pl?ACC=SM000350>.
[2] UniProtKB/Swiss-Prot. "DNA Replication Licensing Factor MCM6 - Homo Sapiens (Human)." DNA Replication Licensing Factor MCM6 - Homo Sapiens (Human). UniProt Consortium, 3 Apr. 2013. Web. 28 Feb. 2013.
[3] SEER Training Modules, Cell Structure and Function. U. S. National Institutes of Health, National Cancer Institute. 18 Feb 2013 <http://training.seer.cancer.gov/>.
[1] "SMART: MCM Domain Annotation." SMART: MCM Domain Annotation. EMBL, 2012. Web. 21 Feb. 2013. <http://smart.embl-heidelberg.de/smart/do_annotation.pl?ACC=SM000350>.
[2] UniProtKB/Swiss-Prot. "DNA Replication Licensing Factor MCM6 - Homo Sapiens (Human)." DNA Replication Licensing Factor MCM6 - Homo Sapiens (Human). UniProt Consortium, 3 Apr. 2013. Web. 28 Feb. 2013.
[3] SEER Training Modules, Cell Structure and Function. U. S. National Institutes of Health, National Cancer Institute. 18 Feb 2013 <http://training.seer.cancer.gov/>.
Page created by: Renae Geier, undergraduate student in genetics at the University of Wisconsin - Madison ([email protected])
Page last updated: 8/26/2013
Page last updated: 8/26/2013